Finest Dietary supplements for Stressed Leg Syndrome (2026) – Zac Johnson

1. Real Science LegEase Miracle – Best Overall

Real Science LegEase Miracle – All Natural Restless Legs Syndrome Relief & Leg Cramp Supplement with Vitamins C, D, K, B6, B12 + Nitric Oxide Support – Sleep & Circulation Aid – Made in USA, 60 Caps

• RELIEF FOR RESTLESS LEGS & CRAMPS: This formula supports full-spectrum restless leg syndrome treatment, easing leg twitching, tingling, cramps, and the urge to move, especially at night when symptoms tend to peak.
• IDEAL FOR RLS SUFFERERS & NIGHTTIME DISCOMFORT: Whether you’re facing age-related restlessness, stress-induced symptoms, or chronic sleep interruption, LegEase Miracle delivers consistent RLS relief that improves with daily use.
• CIRCULATION, NERVE & MUSCLE FUNCTION SUPPORT: Powered by Nobel Prize-winning nitric oxide research, this formula enhances circulation while vitamins C, D, K, B6, and B12 support nerve health and muscle function, delivering whole-leg relief for restless legs.
• NIGHTLY ROUTINE FOR BETTER SLEEP: Just 2 capsules before bed help calm leg agitation and support deeper, uninterrupted rest. This restless leg relief fits easily into your nightly wellness plan; no messy powders, liquids, or prep needed.
• TRUSTED QUALITY FOR RESTLESS LEGS RELIEF: Manufactured in a GMP-certified, FDA-registered facility, this restless legs & leg cramp medicine uses only non-GMO ingredients with no synthetic additives—trusted by thousands seeking natural leg relief.

Built on Nobel Prize-winning nitric oxide research, LegEase Miracle delivers a comprehensive formula specifically designed for restless legs, combining circulation support with essential nerve and muscle cofactors.

Each serving provides vitamins C, D, K, B6, and B12 alongside a proprietary nitric oxide support blend that enhances circulation to the extremities. The formula targets the root causes of RLS — poor circulation, nerve dysfunction, and nutrient deficiencies — rather than simply masking symptoms. Manufactured in a GMP-certified, FDA-registered facility using non-GMO ingredients with no synthetic additives. 60 capsules per bottle, taken as 2 capsules before bed.

• Pros:
• Multi-pathway approach targeting circulation, nerve health, and muscle function
• Specifically formulated for RLS — not a repurposed general supplement
• GMP-certified with no synthetic additives

• Cons:
• Newer brand with less long-term track record
• Proprietary blend doesn’t disclose exact amounts of all ingredients

Best for: RLS sufferers who want a targeted, all-in-one formula designed specifically for restless leg relief

2. Lunakai Magnesium Glycinate Gummies – Best Magnesium for RLS

Sale

Lunakai USA Made Magnesium Glycinate Gummies with L-Theanine for Kids & Adults – 420mg Magnesium Supplement for Calm, Sleep & Stress Support, 60ct

• L-Theanine + Magnesium Gummies — Contains 426mg of magnesium glycinate and L-Theanine in tasty magnesium gummies to support calm and relaxation in chewable form.
• Magnesium Glycinate Gummies for Sleep Support — Helps adults and kids enjoy restful sleep and a peaceful bedtime routine with gentle, non-habit-forming ingredients.
• Gentle Gummies for Adults & Kids — Made with magnesium glycinate, a highly absorbable form that’s easy on digestion and ideal for sensitive stomachs.
• Delicious Magnesium Supplement with Tropical Flavor — Naturally flavored magnesium gummies offer a tasty experience without artificial flavors or preservatives.
• Vegan Magnesium Gummies for Women, Men & Teens — These non-GMO magnesium gummies are free from gluten, dairy, soy, and common allergens to suit various dietary needs

Magnesium glycinate is the most research-supported mineral supplement for RLS, and Lunakai delivers 420 mg per serving in an easily absorbed gummy form with added L-theanine for relaxation.

A 2023 clinical study found that magnesium combined with vitamin B6 relieved RLS symptom severity and improved sleep quality. Magnesium glycinate is preferred over other forms because it offers high absorption, calming effects, and minimal GI side effects. The added L-theanine promotes relaxation without drowsiness — ideal for the anxiety and restlessness that often accompany RLS at bedtime. USA-made, sugar-free options available, and suitable for both kids and adults.

• Pros:
• 420 mg magnesium glycinate — therapeutic dose for RLS
• L-theanine adds calming support for better sleep onset
• Gummy form for those who struggle with swallowing pills at night

• Cons:
• Gummies contain additional ingredients for taste and texture
• May need to take multiple gummies to reach full serving size

Best for: RLS sufferers looking for the most evidence-backed mineral supplement in an easy-to-take form

3. Pink Stork Magnesium Glycinate – Best for Women

Pink Stork Magnesium Glycinate with Vitamin D – Magnesium Supplement for Women to Support Natural Calm, Mood, and Sleep – Hormone Balance for Women – 60 Capsules, 1 Month Supply

• MAGNESIUM MINERAL SUPPLEMENTS: Did you know that most women are not consuming enough magnesium? Pink Stork Magnesium Glycinate contains 100% of the daily recommended Magnesium you need each day – plus Vitamin D3 for mood support. Magnesium plays a crucial part in over 300 biochemical reactions within the body. It helps support energy levels, mood and hormone balance, muscle function, digestive health, and so much more.
• HIGH ABSORPTION + BIOAVAILABLE: Magnesium Glycinate is a highly bioavailable form that’s known for superior absorption and gentle digestion, making it a great option for daily use to help maintain healthy magnesium levels – without the laxative effect often associated with other forms.
• MAGNESIUM FOR CALM: The APA’s 2023 Stress in America survey finds women continue to report higher stress levels than ever before; Magnesium supplementation is proven to support natural calm and overall wellness. Many women do not meet the recommended daily intake of magnesium due to dietary choices and lifestyle factors, including dietary Insufficiency, consumption of processed foods, hormonal factors, and health conditions.
• MAGNESIUM POWDER: Made for women, Pink Stork Magnesium capsules combine Magnesium Glycinate Powder with Vitamin D3 and are designed to fit seamlessly into your wellness routine – whether you’re on the go, at home, or grabbing a quiet moment for self-care. Take them whenever it works best for you; consistency is key. If pills aren’t your thing, open the capsules and pour into your favorite drink, yogurt, or smoothie. Take 2 small capsules daily – each bottle is a one-month supply – and for best results, we recommend consistent use for at least 90 days.
• COUNT ON CLEAN: Our Magnesium supplement for women does not contain GMOs, gluten, soy, or dairy, and is always third-party tested. Formulated by a female team of experts, it also pairs well with Pink Stork Beef Organ Complex, Ashwagandha, Maca Root, and Black Cohosh, or Total Women’s Multivitamin for comprehensive wellness support. Pink Stork’s Magnesium Glycinate is pregnancy- and breastfeeding-friendly and thoughtfully formulated to support women’s wellness at every stage of life. This supplement is designed to be taken alongside other Pink Stork supplements as part of a wellness routine; however, always consult your healthcare provider to ensure your individual needs are met.*

Pink Stork combines magnesium glycinate with vitamin D in a formula designed for women, addressing two of the most common nutrient deficiencies linked to RLS symptoms.

Women are disproportionately affected by RLS, particularly during pregnancy and perimenopause, and often have concurrent magnesium and vitamin D deficiencies. This formula provides highly bioavailable magnesium glycinate alongside vitamin D3 for comprehensive support. The capsule form ensures precise dosing without the added sugars found in gummies. Pink Stork products are specifically formulated for women’s health and are third-party tested for purity.

• Pros:
• Addresses two key RLS-related deficiencies — magnesium and vitamin D
• Formulated specifically for women’s needs
• Clean capsule form without added sugars

• Cons:
• Primarily marketed to women — men may prefer a different option
• Magnesium dose may need supplementation for severe RLS

Best for: Women experiencing RLS, especially those in pregnancy or perimenopause with combined magnesium and vitamin D deficiencies

4. Approved Science Restlex – Best RLS-Specific Formula

HEAL-N-SOOTHE Joint Supplement – Proteolytic Enzymes Formula with Bromelain, Papain, Boswellia, Turmeric & Ginger – Joint Mobility, Muscle Flexibility, Healthy Circulation Wellness – 90 Count (1 Pack)

• TURMERIC BROMELAIN SUPPLEMENT– Heal-n-Soothe combines a powerful blend of both proteolytic enzymes and with important herbal ingredients like turmeric, ginger, and boswellia to alleviate discomfort in knees, joints, and muscles, improving cartilage flexibility for both women and men.
• PROMOTES CIRCULATION & DIGESTION – Proteolytic enzymes in Heal-n-Soothe work to break down unwanted protein blockage and stimulate circulation, assisting digestion, and encouraging healthy tissues and a cleaner gut.
• PREMIUM ENZYME BLEND – Featuring a potent mix of proteolytic enzymes, turmeric extract, bromelain, and more, this supplement promotes efficient protein metabolism, body function, and circulatory health, targeting pain at its root.
• PROMOTES STRONG BODY DEFENSES – Heal-n-Soothe delivers a potent blend of proteolytic enzymes and botanical extracts such as turmeric and bromelain, working in harmony to uphold the body’s protective functions and encourage lasting wellness.
• QUALITY FORMULA – Tested and blended in the USA, Heal-n-Soothe is a vegetarian, non-GMO, gluten-free supplement with no dairy, added dietary sugar or unnecessary fillers, combining proteolytic enzymes, Mojave Yucca Root, Devil’s Claw, turmeric, and bromelain to support joint and muscle wellness.

Restlex is specifically engineered for restless leg syndrome, delivering 420 mg of magnesium glycinate paired with 200 mg of L-theanine in a science-backed combination that targets muscle relaxation and stress relief.

This formula focuses on the two primary mechanisms behind nighttime RLS — magnesium deficiency and nervous system hyperexcitability. Magnesium glycinate was chosen for its high absorption and ability to cross the blood-brain barrier, while L-theanine promotes alpha brain wave activity associated with calm relaxation. 60 capsules per bottle, taken as 2 capsules daily, preferably before bed. Manufactured in a GMP-certified facility.

• Pros:
• Purpose-built formula for RLS with research-backed doses
• 420 mg magnesium glycinate — the most effective form for neuromuscular relaxation
• L-theanine targets the nervous system component of RLS

• Cons:
• Only addresses magnesium and relaxation — may need to stack with iron and B vitamins
• 30-day supply only per bottle

Best for: Those who want a clinically focused RLS supplement built around the magnesium glycinate and L-theanine combination

5. Nature Made Iron 65mg – Best Iron for RLS

DEVA Vegan Vitamin B12 Fast Dissolve Supplement – Once-Per-Day Complex with 1000 Mcg Methylcobalamin B12, Folic Acid, B6 – Lemon Flavor – 90 Dissolvable Tablets, 2-Pack

• ESSENTIAL DAILY DOSE OF B12 – An important vitamin for maintaining healthy nerve cells, B12, is not significantly found in plant foods. Deva Vegan B12 supplements are available in the more bioavailable form of Methylcobalamin and provide 1000 mcg each.
• EASY-TO-TAKE LOZENGE TABLETS – B12 Deva is a small, fast disintegrating tablet that dissolves in the mouth before swallowing. Tablets are pleasant tasting and can also be chewed if desired, so people who have difficulty swallowing pills can take it easily.
• POTENT SOURCE OF B6 AND FOLIC ACID: These b12 vitamins for elderly women and men are packed with B6 and Folic Acid, so you get three important vitamins in one small lozenge.
• TAILORED FOR VEGANS & VEGETARIANS – This B12 supplement is suitable for vegans and vegetarians. It does not contain any milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, or soy allergens.
• 100% CUSTOMER SATISFACTION – If, for any reason, you’re unhappy with our vegan vitamins, let us know anytime so we can provide a full purchase refund or replacement–no questions asked.

Iron is the most studied and recommended supplement for RLS — the American Academy of Sleep Medicine recommends iron replacement as first-line therapy for anyone with RLS and low ferritin levels.

Nature Made provides 65 mg of elemental iron from ferrous sulfate, the most clinically studied form. The AASM recommends targeting ferritin levels above 75 mcg/L for RLS patients, which often requires supplementation even when levels appear “normal” by standard lab ranges. Nature Made is one of the most trusted supplement brands in the US, USP verified for quality and purity, and widely recommended by healthcare providers. 180 tablets per bottle for a 6-month supply.

• Pros:
• Most evidence-backed supplement for RLS — AASM first-line recommendation
• USP verified for purity, potency, and dissolution
• Excellent value — 6-month supply per bottle

• Cons:
• Ferrous sulfate can cause constipation and GI discomfort in some people
• Should only be taken after blood testing confirms low ferritin — excess iron is harmful

Best for: RLS patients with confirmed low ferritin levels (below 75 mcg/L) who need a trusted, affordable iron supplement

6. Sugar-Free Magnesium Glycinate Chewable – Best Value

Sugar Free Magnesium Glycinate Chewable – Chewable Magnesium for Adults & Kids with Glycinate Taurate & Citrate Complex Plus Vitamins D3 B6 & C – Vegetarian Non-GMO & No Artificial Flavors – 60 Count

• 3X Magnesium Chews – We feature a synergistic blend of high absorption magnesium glycinate and citrate with taurate in our triple complex magnesium chewable formula to give you maximum benefits
• Gummy Alternative – Ditch those sugary magnesium glycinate gummies with little elemental magnesium and try our sugar free chewable magnesium glycinate 200mg complex that adults and kids alike enjoy
• High Absorption Formula – Not all magnesium is equal which is why we carefully blended a magnesium glycinate complex which offers higher bioavailability that works together with vitamin D3 B6 and C
• Clean Label – Our gluten free magnesium glycinate supplement is proudly made & tested in American GMP ISO labs made without GMOS or artificial flavors and colors so you can supplement in confidence
• Natures Craft Quality – We are proud to be a leading name in a wide range of magnesium supplements including capsules and gummies because we believe there are no one size fits all wellness solutions

This sugar-free chewable delivers magnesium glycinate with GABA support in an affordable, easy-to-take format that’s suitable for both adults and children experiencing nighttime leg discomfort.

The chewable form offers an alternative for those who have difficulty swallowing capsules, which can be especially useful for older adults — a demographic disproportionately affected by RLS. Magnesium glycinate provides calming muscle relaxation while the added GABA supports nervous system regulation. Sugar-free formulation avoids blood sugar spikes before bedtime. Budget-friendly pricing makes it accessible for daily long-term use.

• Pros:
• Chewable form — ideal for pill-averse individuals and seniors
• Sugar-free for bedtime use without blood sugar concerns
• Magnesium glycinate with GABA for dual muscle and nerve support

• Cons:
• Lower magnesium dose per chewable compared to capsule alternatives
• Chewable flavoring may not appeal to all taste preferences

Best for: Seniors and those who prefer a chewable magnesium supplement for nightly RLS support at a budget-friendly price

7. DaVinci Labs ADK 10 – Best Vitamin D for RLS

DAVINCI Labs ADK 10 – Helps Support Bone, Heart & Immune Health – Dietary Supplement with Vitamins A, D3 & K2 (as MK-7) – Vegetarian, Gluten Free & Soy Free – 90 Capsules

• ADK Vitamin Supplement: ADK 10 is a powerful dietary supplement designed to support bone structure, density and integrity; also aids in proper bone remodeling and calcium utilization
• Heart Health Supplements: ADK 10 is also a heart health supplement, providing circulatory support to support your optimal heart functioning
• Bone Strength Supplements: With 1,500 mcg of Vitamin A in each serving, ADK 10 supports calcium absorption and supports strong bones and teeth, making it a superior choice in bone strength supplements
• Vitamin K Presence: Our formula includes Vitamin K2, a unique form that activates the benefits of vitamins D and A, while supporting circulatory function
• About DaVinci: Since 1973, we have been a leader in nutritional research, product development and innovation with our emphasis on quality

Research links vitamin D deficiency to increased RLS incidence and severity, and DaVinci Labs ADK 10 provides a clinically formulated combination of vitamins A, D3, and K2 for optimal absorption and utilization.

Studies show that people with RLS often have lower vitamin D levels than those without the condition. DaVinci Labs ADK 10 delivers vitamin D3 alongside vitamins A and K2 — essential cofactors that improve vitamin D metabolism and prevent calcium misplacement. This professional-grade formula is used in clinical settings and manufactured under strict GMP standards. The K2 component as MK-7 also shows promise for reducing nocturnal muscle cramps, which frequently overlap with RLS symptoms.

• Pros:
• Comprehensive A, D3, and K2 formula for synergistic vitamin D support
• Professional-grade quality used in clinical settings
• K2 (MK-7) may additionally help with nocturnal leg cramps

• Cons:
• Requires blood testing to optimize vitamin D dosing
• Does not address magnesium or iron — the primary RLS supplements

Best for: RLS sufferers with confirmed low vitamin D levels who want a comprehensive fat-soluble vitamin formula

How to Choose the Best Supplement for Restless Leg Syndrome

The most effective supplement strategy for RLS depends on identifying your underlying deficiency. Start with blood testing for ferritin (target above 75 mcg/L for RLS), vitamin D, and magnesium levels. Iron is the single most evidence-backed supplement for RLS and should be the first consideration if ferritin levels are low, but should not be taken without testing since excess iron causes its own health issues.

Magnesium glycinate is the preferred form for RLS because it has high bioavailability, calming properties, and fewer GI side effects than magnesium oxide or citrate. A 2023 study found that combining magnesium with vitamin B6 improved both RLS severity and sleep quality. Look for supplements providing at least 300–420 mg of elemental magnesium glycinate, taken before bed for maximum benefit.

Beyond single nutrients, consider that RLS often involves multiple contributing factors — circulation, nerve health, and sleep quality. Multi-ingredient formulas that combine magnesium with circulation-supporting compounds like L-theanine, B vitamins, and vitamin D3 can address more pathways simultaneously. Take iron separately from magnesium by at least 2 hours, as they compete for absorption.

Look for USP or NSF verification, GMP certification, and third-party testing. Avoid supplements with excessive fillers or stimulants like caffeine, which can worsen RLS symptoms. For iron supplements, consider taking with vitamin C to enhance absorption.

Frequently Asked Questions

What is restless leg syndrome and what causes it?

Restless Leg Syndrome (RLS) is a neurological disorder affecting 7–10% of the US population, causing an irresistible urge to move the legs, usually accompanied by uncomfortable sensations like tingling, crawling, or aching. Symptoms typically worsen at night and during periods of rest. Causes include iron deficiency in the brain, genetic factors, pregnancy, kidney disorders, nerve damage, and certain medications. Nutrient deficiencies in iron, magnesium, vitamin D, and B vitamins are commonly associated with RLS.

How much magnesium should I take for restless legs?

Most studies use 300–420 mg of elemental magnesium daily for RLS, with magnesium glycinate being the preferred form due to its high absorption and calming effects. Take it 30–60 minutes before bed for maximum benefit. Start with a lower dose (200 mg) and increase gradually to avoid loose stools, which are more common with less absorbable forms like magnesium oxide.

When is the best time to take RLS supplements?

Magnesium and multi-ingredient RLS formulas are best taken 30–60 minutes before bed when RLS symptoms are most problematic. Iron supplements should be taken on an empty stomach (or with vitamin C) for best absorption — morning is often preferred since iron can cause stomach discomfort. Vitamin D can be taken at any time with a fat-containing meal.

Should I take iron for restless legs without testing?

No. Iron should only be taken after blood testing confirms low ferritin levels. The American Academy of Sleep Medicine recommends iron supplementation only when serum ferritin is below 75 mcg/L. Excess iron can cause hemochromatosis and organ damage. Get a comprehensive iron panel including serum ferritin, serum iron, TIBC, and transferrin saturation before supplementing.

Can I take magnesium and iron together for RLS?

While both are beneficial for RLS, magnesium and iron compete for absorption when taken simultaneously. Separate them by at least 2 hours — take iron in the morning on an empty stomach and magnesium before bed. This also aligns with optimal timing since magnesium’s calming effects are most useful at nighttime when RLS symptoms peak.

How long does it take for supplements to help restless legs?

Magnesium supplements may provide noticeable relief within 1–2 weeks of consistent nightly use. Iron supplementation typically takes 4–12 weeks to significantly raise ferritin levels and reduce RLS symptoms. Vitamin D repletion can take 2–3 months. Multi-ingredient RLS formulas usually show improvement within 2–4 weeks. Consistency is key — sporadic use is unlikely to provide sustained benefit.

Related Articles