At 70, Kris Jenner still runs an empire. She’s up before most people have hit their first snooze button, firing off emails, taking calls, managing careers, building businesses, and somehow still making time to show up to dinner with her kids looking like she just stepped off a red carpet.
For years, people have watched her closely, wondering, speculating, and sometimes whispering about how she keeps it all together… and how she keeps looking the way she does. The theories have been loud, relentless, and very public.
But this week, for the first time, the momager sat down and actually answered the question everyone has been too polite… or too nosy to ask outright: Did she take Ozempic or didn’t she? Turns out, the answer is yes. And no. And the full story is a whole lot more interesting than either of those answers.
During a Tuesday, May 5 appearance on the SHE MD Podcast, hosted by OBGYN Dr. Thaïs Aliabadi and women’s advocate Mary Alice Haney, Jenner opened up about something she had never publicly confirmed before.
She tried Ozempic. She tried it early, before it became the cultural obsession it is today, before it was the word on everyone’s lips at dinner parties and the punchline of every late-night monologue.
And it knocked her flat. “I did not do, like, an Ozempic,” she told the hosts. “I tried it. We tried it once when no one knew what it was, and it made me really sick.”
When the Wonder Drug Isn’t So Wonderful
What followed was the kind of raw, unscripted moment that Kris Jenner rarely gives us. She recalled calling up Dr. Aliabadi, her personal physician and one of the podcast’s hosts, at the end of her rope. “I can’t work anymore,” she told her. “I can’t. I’m so sick. I can’t, like… nauseous.”
And just like that, the medication that millions of people had been chasing prescriptions for, the one that turned Hollywood into a waiting room, was off the table for her. Dr. Aliabadi’s response was straightforward, “Okay, let’s try something else.”
It might be easy to brush this off as a celebrity casually admitting to dabbling in a trend, but the reality of what Jenner described is something that an enormous number of people have quietly lived through and rarely talk about.
Ozempic, known generically as semaglutide, was originally developed as a treatment for Type 2 diabetes. Its appetite-suppressing effects made it a word-of-mouth sensation in Hollywood long before it became a mainstream conversation. But the drug’s most common side effect, nausea, is no small inconvenience.
According to clinical trial data, up to 20% of people taking Ozempic for diabetes reported nausea, and rates were even higher among those using it for weight loss.
Research published in peer-reviewed literature found that gastrointestinal complaints affected anywhere from 41.9% to 82.8% of semaglutide users, depending on dosage.
One study tracking real-world patients found that 33% discontinued treatment within 12 months, and another found that 70% had discontinued treatment within 2 years. Kris Jenner, it turns out, was not the exception. She was, quietly, the majority.
The “Game Changer” She Actually Swears By
Once Ozempic was out, Dr. Aliabadi helped Jenner find a path that actually fit her body and her lifestyle. What she landed on was a combination of peptide injections and supplements, and she is not shy about crediting them with changing how she functions daily.
“I realised that a peptide injection was really great for me,” Jenner said. “And then I follow it up with supplements.” The results, she explained, weren’t just cosmetic. They were practical. “That actually bought me an extra couple hours at night. Because I get up so early, I tend to want to go and collapse as soon as I have my last email or my last call or see my kids and have dinner and I’m done.”
The supplements, she noted with the kind of casual confidence only Kris Jenner can pull off, helped her hair, nails, and skin. Dr. Aliabadi guided her toward things like fish oils and omega-3s.
But the change that has arguably made the biggest difference in how Jenner manages her health has nothing to do with injections or supplements. It is something far simpler, and far more overlooked.
“I get my blood drawn every three months just to keep my hormones balanced,” she explained. “It was really a game changer for me, because when you look at your thyroid, you look at your hormone health, you look at what your body needs.”
She went on to say she first realized this after turning 45, describing regular hormone monitoring as critical to physical female health, and, she added, male health too. “I encourage my son to check his hormones to see what’s happening.”
The Speculation That Preceded the Confession
The reason this week’s podcast moment landed with such weight is that Jenner has been dogged by Ozempic speculation for nearly three years. In the summer of 2023, she posted vacation photos on Instagram, and the internet did what the internet does.
The phrase “Ozempic baddie” made the rounds. People analyzed her frame, her face, her everything. The Kardashian-Jenner family had already become a kind of cultural barometer for celebrity weight-loss drug use, with Khloé Kardashian pushing back hard in January of that same year against suggestions she was taking it.
“Let’s not discredit my years of working out,” Khloé wrote, adding that she trained five days a week starting at 6 a.m. By December 2024, though, Khloé’s tone had shifted. “Who cares?” she told Bustle. “As long as people feel good about themselves.”
Meanwhile, Scott Disick’s situation played out in a rather different register entirely. Eagle-eyed fans spotted Mounjaro, a similar GLP-1 medication, in his fridge during a 2024 episode of The Kardashians.
He eventually broke his silence in a February 2025 episode, delivering what may be the most unfiltered GLP-1 commentary of the entire era. Against that backdrop, Kris’s measured, candid admission on the SHE MD Podcast carries a different kind of energy.
She is not performing indignation. She is not performing shame. She is just telling you what happened and what she does now.
The Part of This Story Nobody Is Talking About
Here is where things get genuinely interesting, and where this story deserves more than a passing scroll. Kris Jenner is not just describing a personal wellness pivot.
She is, perhaps unintentionally, flagging a tension at the heart of the entire GLP-1 moment and pointing toward something the conversation around Ozempic has largely crowded out.
The peptide injections Jenner credits as her “game changer” exist in a very different regulatory landscape than Ozempic. Peptide therapy has exploded in Hollywood and wellness circles, with celebrities including Gwyneth Paltrow and LeAnn Rimes openly praising the treatments for their claimed benefits to energy, skin, hair, and recovery.
But the science, by the candid admission of medical experts, has not kept pace with the enthusiasm. Dr. Eric Topol, cardiologist and director of Scripps Research Translational Institute, has put it plainly: “There isn’t any meaningful data on these peptides. People are taking them on blind faith.”
Most of the popular peptide injections making the rounds in Beverly Hills clinics have not been FDA-approved for the uses for which people are paying. Clinical evidence remains, as more than one board-certified dermatologist has noted, limited in scope and scale.
To be fair to Jenner, she is not taking any peptide off a gray-market website. She is working with a personal physician who is monitoring her hormones every three months and guiding her supplements.
That is a fundamentally different situation from someone self-prescribing from an unregulated online supplier. But her story, told as a triumphant discovery of “what finally worked,” deserves to be held alongside the full picture: the treatment she promotes as a game changer is one the broader medical community is still working to fully evaluate.
Ozempic, with all its brutal nausea and very real discontinuation rates, at least has clinical trial data. The peptide world is, by and large, still building its case. None of this makes Jenner wrong for choosing what she chose. Her body, her rules.
But it does make the narrative slightly more complicated than the feel-good wellness win it has been framed as, and it raises a question worth sitting with: when a woman with Kris Jenner’s platform says something is a game changer, how much of what follows is medicine and how much is momentum?
What She Wants You To Borrow From Her Playbook
Strip away the celebrity context for a moment, and what Jenner is actually advocating for is fairly sound. The quarterly blood draws, the hormone monitoring, the thyroid checks, the attention to what her specific body actually needs rather than what is trending, that part of her story is not controversial at all.
The emphasis on understanding your own hormones after 45 is something practitioners in women’s health have been urging for years without nearly enough fanfare.
The fact that it took Kris Jenner saying it on a podcast to get it into the conversation is, depending on your perspective, either frustrating or just the way the world works.
She also, during the same podcast appearance, addressed the facelift that became a talking point in 2025. “I had a very well-known facelift a year ago. So that was helpful,” she said, laughing, before crediting her surgeon, Dr. Steven Levine.
She flat-out denied reports that she was unhappy with the results, calling the headline a “flat-out lie” and saying she is “obsessed” with her doctor.
For someone with a long history of carefully curated public presentation, there was something almost refreshing about how unguarded this entire conversation felt.
At 70, Kris Jenner is not pretending the work isn’t happening. She is just finally, and very selectively, telling you what the work actually is.
