Finest Dietary supplements for Raynaud’s Syndrome (2026) – Zac Johnson

1. Lunakai Nattokinase – Best Overall

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Lunakai USA Made Nattokinase Supplement – 400mg Natto Enzyme, 8000 FU per Serving – Heart & Circulation Support – Non-GMO, 60ct, 4000 FU Capsule

• Supports Circulation – Each serving delivers 8000 FU of nattokinase, traditionally sourced to assist in supporting normal blood flow.
• Natural Heart Support – Our nattokinase supplement is formulated to complement daily routines focused on overall heart wellness support.
• Clean & Simple Ingredients – Each capsule contains 200mg of nattokinase enzyme, delivering 4000 FU, sourced from fermented natto with no artificial flavors or additives.
• Vegan-Friendly Formula – Our nattokinase supplement is 100% vegan and plant-based, with no animal-derived ingredients or gelatin.
• Made in the USA – Manufactured in the United States in a facility that follows GMP (Good Manufacturing Practices) for quality and consistency.

Nattokinase supports cardiovascular and circulatory health by promoting healthy blood flow and fibrinolytic activity — key factors for preventing the excessive vasoconstriction that defines Raynaud’s attacks.

Lunakai’s Nattokinase supplement delivers 400mg (8,000 FU) per serving of this enzyme derived from the Japanese fermented soy food natto. Nattokinase supports healthy circulation by maintaining normal fibrinogen levels and promoting blood flow through small vessels — exactly where Raynaud’s symptoms occur. The formula supports endothelial function and vascular health, addressing the underlying circulatory dysfunction that makes Raynaud’s patients vulnerable to cold-triggered vasospasm. Manufactured in the USA with strict quality standards and third-party tested for purity.

• Pros:
• Supports healthy blood flow through small peripheral vessels
• High potency at 8,000 FU per serving
• Manufactured in USA with third-party testing

• Cons:
• Should not be combined with blood-thinning medications without medical supervision
• Derived from soy — not suitable for those with soy allergies

Best for: Raynaud’s sufferers looking for comprehensive circulatory support that targets blood flow through peripheral vessels

2. NutraChamps L-Arginine with L-Citrulline – Best for Nitric Oxide Support

L-Arginine Capsules with L-Citrulline – Nitric Oxide Supplement – L Arginine and L Citrulline Blend – 120 Count – Vegan, Non-GMO Capsules for Performance, Endurance and Muscle Support – 2 Month Supply

• L-Arginine L-Citrulline Complex – Each serving contains a 1200mg blend of L-Arginine and L-Citrulline, ensuring maximum performance and muscle support during physical activities.
• Supports Nitric Oxide Production – Our l arginine supplement for men and women helps support nitric oxide production, which may promote peak performance during exercise and support overall physical vitality.
• Exercise Endurance – Fuel your active lifestyle with l-arginine for men and women, formulated to assist with endurance and recovery, helping you stay on top of your fitness goals.
• Two-Month Supply – With 120 capsules per bottle, our L-Arginine and L-Citrulline supplement offers a convenient 2-month supply, providing long-term support for your fitness and wellness goals with ease.
• Vegan & Non-GMO – Crafted with vegan and non-GMO ingredients, our L-Arginine capsules are produced to meet high standards, ensuring you get a reliable and hassle-free supplement for your active lifestyle.

L-Arginine is the direct precursor to nitric oxide — the body’s primary vasodilator — and clinical case reports show oral L-arginine can reverse digital necrosis in severe Raynaud’s cases.

This formula combines L-arginine with L-citrulline for sustained nitric oxide production. Nitric oxide signals smooth muscles in vessel walls to relax, directly counteracting the excessive vasoconstriction that causes Raynaud’s attacks. Clinical case reports using 2-6 grams of L-arginine daily showed reversal of digital necrosis and significant symptom improvement in Raynaud’s patients. L-Citrulline extends the duration of NO production since the body converts it to L-arginine over time, providing a more sustained vasodilatory effect than L-arginine alone.

• Pros:
• Directly targets the nitric oxide pathway central to Raynaud’s
• Dual amino acid formula for sustained vasodilation
• Clinical case reports demonstrate efficacy in severe Raynaud’s

• Cons:
• May cause digestive discomfort at higher doses
• Not recommended with PDE-5 inhibitors or nitrate medications

Best for: Raynaud’s patients seeking targeted nitric oxide support to improve blood flow to fingers and toes

3. Pink Stork Magnesium Glycinate – Best Natural Calcium Channel Blocker

Pink Stork Magnesium Glycinate with Vitamin D – Magnesium Supplement for Women to Support Natural Calm, Mood, and Sleep – Hormone Balance for Women – 60 Capsules, 1 Month Supply

• MAGNESIUM MINERAL SUPPLEMENTS: Did you know that most women are not consuming enough magnesium? Pink Stork Magnesium Glycinate contains 100% of the daily recommended Magnesium you need each day – plus Vitamin D3 for mood support. Magnesium plays a crucial part in over 300 biochemical reactions within the body. It helps support energy levels, mood and hormone balance, muscle function, digestive health, and so much more.
• HIGH ABSORPTION + BIOAVAILABLE: Magnesium Glycinate is a highly bioavailable form that’s known for superior absorption and gentle digestion, making it a great option for daily use to help maintain healthy magnesium levels – without the laxative effect often associated with other forms.
• MAGNESIUM FOR CALM: The APA’s 2023 Stress in America survey finds women continue to report higher stress levels than ever before; Magnesium supplementation is proven to support natural calm and overall wellness. Many women do not meet the recommended daily intake of magnesium due to dietary choices and lifestyle factors, including dietary Insufficiency, consumption of processed foods, hormonal factors, and health conditions.
• MAGNESIUM POWDER: Made for women, Pink Stork Magnesium capsules combine Magnesium Glycinate Powder with Vitamin D3 and are designed to fit seamlessly into your wellness routine – whether you’re on the go, at home, or grabbing a quiet moment for self-care. Take them whenever it works best for you; consistency is key. If pills aren’t your thing, open the capsules and pour into your favorite drink, yogurt, or smoothie. Take 2 small capsules daily – each bottle is a one-month supply – and for best results, we recommend consistent use for at least 90 days.
• COUNT ON CLEAN: Our Magnesium supplement for women does not contain GMOs, gluten, soy, or dairy, and is always third-party tested. Formulated by a female team of experts, it also pairs well with Pink Stork Beef Organ Complex, Ashwagandha, Maca Root, and Black Cohosh, or Total Women’s Multivitamin for comprehensive wellness support. Pink Stork’s Magnesium Glycinate is pregnancy- and breastfeeding-friendly and thoughtfully formulated to support women’s wellness at every stage of life. This supplement is designed to be taken alongside other Pink Stork supplements as part of a wellness routine; however, always consult your healthcare provider to ensure your individual needs are met.*

Magnesium acts as a natural calcium channel blocker — the same mechanism used by the most commonly prescribed Raynaud’s medications — by helping relax smooth muscles in blood vessel walls.

Research shows decreased serum magnesium levels are more common in women with primary Raynaud’s than in healthy women. Magnesium blocks calcium that constricts blood vessels, dilates blood vessels to improve blood flow, and increases nitric oxide production. This glycinate form offers superior bioavailability and is gentle on the stomach. The added Vitamin D provides additional vascular support, as Vitamin D deficiency is associated with impaired endothelial function. Magnesium requirements also increase with physical and emotional stress — both known Raynaud’s triggers.

• Pros:
• Mimics the mechanism of prescription calcium channel blockers
• Studies link low magnesium to increased Raynaud’s prevalence
• Glycinate form is highly absorbed and gentle on digestion

• Cons:
• May not be sufficient as a standalone treatment for severe Raynaud’s
• Effects are gradual — requires consistent daily use

Best for: Raynaud’s sufferers looking for a foundational supplement that addresses vascular relaxation through the same pathway as prescription drugs

4. NATURELO Omega-3 Fish Oil – Best Anti-Inflammatory

NATURELO Burpless Omega 3 Fish Oil Supplement – 1100mg Triglyceride Omega-3, EPA + DHA, Liquid Fish Oil for Heart, Eye, Brain, Joint Health – 60 Softgels, 2 Months Supply

• NO BURPS, FRESH FLAVOR: The fish oil supplements burpless formula works to prevent a fishy smell or fishy aftertaste, maintaining freshness with a hint of lemon. Omega 3 fish oil is burpless, giving you comfort and great taste.
• HIGH ABSORPTION: The fish oil omega 3 supplements use the Triglyceride form of Omega-3 to support absorption. Each softgel packs a potent 1100 mg of Omega-3, requiring only one capsule per day to help meet your omega-3 DHA and EPA fatty acid needs.
• PURE AND SUSTAINABLE: This omega-3 fish oil is sourced and purified in the United States from sustainable, wild-caught Alaskan Pollock. Advanced molecular distillation techniques are used, creating high quality fish oil omega 3 supplements.
• HEALTH BENEFITS: Fish oils omega 3 fatty acids can support several health benefits including heart, brain, eye, and joint health function. This Omega-3 fish oil supplement can help fill the omega 3 fatty acids nutrient gap if your diet lacks fish and other dietary sources of omega-3 fats.
• EXTENDED SUPPLY: One bottle offers a 2-month supply, with our liquid omega 3 fish oil formula requiring only one softgel per day.

Fish oil supplementation increased the time before Raynaud’s symptoms appeared after cold exposure and significantly improved finger blood flow in a clinical trial of primary Raynaud’s patients.

NATURELO provides 1,100mg of triglyceride-form omega-3s per serving with a balanced EPA + DHA profile. A clinical study found that fish oil capsules containing EPA and DHA taken for 12 weeks increased cold tolerance and significantly improved digital blood flow in primary Raynaud’s patients compared to placebo. Omega-3s reduce blood viscosity, making red blood cells and platelets less sticky so blood flows more easily through the narrow capillaries affected by Raynaud’s. The triglyceride form offers better absorption than ethyl ester alternatives, and the burpless coating eliminates fishy aftertaste.

• Pros:
• Clinical trial evidence specifically in Raynaud’s patients
• Reduces blood viscosity for improved microcirculation
• Sustainably sourced with heavy metal testing

• Cons:
• Fish oil was effective for primary but not secondary Raynaud’s in studies
• Requires consistent daily use for several weeks

Best for: Primary Raynaud’s patients seeking to improve cold tolerance and peripheral blood flow with a clinically studied supplement

5. PurePremium Blood Pressure Support – Best Herbal Circulation Blend

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PurePremium Blood Pressure Supplements with Hawthorn Berry, Hibiscus, Garlic & Vitamin B12- Nitric Oxide Supplement for Normal Heart Health, Circulation Health & Blood Pressure Support – 90ct

• NORMAL BLOOD PRESSURE SUPPORT: Support normal nitric oxide and blood pressure levels already within the normal range with our advanced herbal formula. Crafted from the finest ingredients, it contains potent vitamins for your wellbeing. Take 1 capsule daily of our natural blood pressure support supplement.
• NORMAL NITRIC OXIDE SUPPORT: Unlike other nitric oxide supplements for men, PurePremium offers highly absorbable, fast-acting formula. This makes our blood pressure support supplement a perfect nitric oxide supplement for supporting normal cardiovascular health.
• ALL IN ONE FORMULA: Experience a blend of nutrients in our blood pressure supplements, featuring, hawthorn berry, hibiscus, garlic extract, olive leaf, buchu leaf, uva ursi, juniper berry, green tea, vitamin C, niacin, vitamin B6, folate, and vitamin B12.
• USA-MADE, LAB TESTED: PurePremium Blood Pressure Support supplement is manufactured in a USA-based facility with globally sourced ingredients. Each batch of our nitric oxide supplement is tested by a third-party lab to ensure safety.
• CAUTION: CONSULT A HEALTHCARE PROFESSIONAL BEFORE USE: Individuals with pre-existing medical conditions or those taking prescription medications should consult with a healthcare professional before using this supplement. Follow recommended dosage instructions. Seek medical advice for adverse effects.

This multi-herb formula combines hawthorn berry, hibiscus, and garlic — three botanicals traditionally used to support healthy blood vessel dilation and peripheral circulation.

PurePremium’s formula delivers a comprehensive herbal approach to vascular health with hawthorn berry (known for improving blood flow to extremities), hibiscus (which supports healthy blood pressure through vasodilation), and garlic (a natural nitric oxide booster). The Raynaud’s Association specifically recommends garlic and warming herbs as dietary additions for circulation support. The formula also includes Vitamin B12, which supports red blood cell production and nerve health — both relevant for Raynaud’s patients experiencing numbness and tingling.

• Pros:
• Multiple circulation-supporting herbs in one formula
• Garlic supports natural nitric oxide production
• Includes B12 for nerve health and red blood cell support

• Cons:
• Not specifically formulated for Raynaud’s
• Garlic may cause digestive discomfort in some users

Best for: Raynaud’s patients who prefer a multi-herb approach to circulation support rather than single-ingredient supplements

6. OmniBiotics Evening Primrose Oil – Best for GLA Support

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OmniBiotics Organic Evening Primrose Oil for Women – Clinical Strength 1500mg per Capsule, 10% GLA, Cold-Pressed, Non-GMO, Hormone Balance for Women – 120 Vegan Softgel Capsules

• ORGANIC & PURE – Our Evening Primrose Oil is cold-pressed from organic evening primrose seeds so that you get the purest product possible. Each serving contains 1,500mg of evening primrose oil and 150mg of GLA (Gamma-Linolenic Acid) for maximum strength. No other primrose oil supplement compares.
• NATURAL BALANCE & FEMALE SUPPORT – Evening
 Primrose Oil can help support natural balance in women. Primrose oil also supports other aspects of female health.
• SUPPORTS HEALTHY JOINTS – People often use OmniBiotics organic primrose oil supplement for supporting joint health and improving morning stiffness.
• 100% NATURAL, NON-GMO, NO BINDERS or ADDITIVES – Our clinical-strength organic Evening Primrose Oil (EPO) is 100% natural and free of: gluten, soy, nuts, dairy, sugar, animal by-products, artificial ingredients, chemicals, preservatives and fillers. You get pure, high quality ingredients and nothing else. All manufacturing is done within the USA in a NSF-certified, cGMP facility.

Evening primrose oil contains gamma-linolenic acid (GLA), and research shows it significantly reduced both the number and severity of Raynaud’s attacks in a clinical study of primary Raynaud’s patients.

OmniBiotics delivers a clinical-strength 1,500mg dose of organic evening primrose oil per capsule, providing a concentrated source of GLA (gamma-linolenic acid). A clinical study found that evening primrose oil taken for 8 weeks significantly reduced the number and severity of primary Raynaud’s attacks by limiting prostaglandin-mediated vasoconstriction. GLA helps regulate inflammatory pathways that contribute to blood vessel constriction, and it supports healthy immune function relevant for those with autoimmune-related secondary Raynaud’s. The organic formulation is cold-pressed to preserve fatty acid integrity.

• Pros:
• Clinical study showed reduced Raynaud’s attack frequency and severity
• High-potency 1,500mg dose per capsule
• Organic, cold-pressed formulation preserves GLA content

• Cons:
• May take 6-8 weeks for noticeable effects
• Not suitable for those on blood-thinning medications without supervision

Best for: Primary Raynaud’s patients looking for a fatty acid supplement with specific clinical evidence for reducing attack frequency

7. Niacin (Vitamin B3) – Best for Vasodilation

Vitamin B3 Niacinamide 500mg Capsules – Mitochondrial Energy and Potent Skin Supplement – AKA Vitamin B3 Niacin 500mg Flush Free and Nicotinamide 500mg – Flush Free Niacin Supplement – 240 Count

• Many Names Same Great Product – B3 vitamins go by many names but rest assured our niacinamide supplement is packed with pure and simple nicotinamide 500 mg a more optimized form of no flush niacin
• Potent Supplement – Try our potent antioxidant niacin flush free energy supplement and feel rejuvenated with the water-soluble active form of vitamin B3 that supports energy levels from within
• Vitamin B for Skin – Niacinamide is a great way to protect your skin from within by supporting the skin barrier by enhancing the immune system and supporting mitochondria for faster cell cycles
• Brain Health Supplement – Nicotinamide is a a great brain supplement for focus, energy, memory & clarity as it can help promote brain enzymes and cognitive function as one of the top brain vitamins
• Natures Craft Quality – We are proud to be a leading name in specialty supplements because we care about providing superior quality products to consumers like you who deserve nothing but the best

Niacin is one of the most recognized supplements for promoting blood vessel dilation, and the Raynaud’s Association recommends it for its ability to promote circulation and dilate small blood vessels.

This 500mg niacinamide formula provides Vitamin B3 in a form that supports vascular health and mitochondrial energy production. Niacin promotes circulation by dilating blood vessels, particularly the small peripheral vessels affected by Raynaud’s. The Raynaud’s Association specifically recommends starting with 50-100mg of niacin daily for circulation support. The niacinamide form used here avoids the uncomfortable flushing associated with regular niacin while still providing B3’s benefits for vascular and cellular health. Each bottle provides a 6-month supply.

• Pros:
• Specifically recommended by the Raynaud’s Association
• Niacinamide form avoids the flushing side effect of regular niacin
• Excellent value — 6-month supply per bottle

• Cons:
• Niacinamide has less vasodilatory effect than niacin (nicotinic acid)
• Some Raynaud’s patients may benefit from the flush-producing form instead

Best for: Raynaud’s patients seeking a well-tolerated B-vitamin for vascular support and circulation enhancement

8. Lunakai Turmeric Gummies – Best for Vascular Inflammation

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Lunakai USA Made Turmeric Gummies with Ginger & BioPerine – High Absorption Turmeric and Ginger Supplement for Inflammation, Joint & Immune Support, 60ct

• Turmeric Curcumin and Ginger Supplement with BioPerine – Features turmeric, ginger, and black pepper extract (BioPerine) to support absorption in a tasty gummy format for daily use.
• Joint & Inflammation Support for Adults and Kids – Turmeric and ginger work together to help support joint function and occasional inflammation in both adults and children.
• Immune System Support from Natural Ingredients – Supports your immune system with natural turmeric curcumin and ginger in a chewable gummy. Perfect for your daily wellness routine.
• Turmeric Gummies with Ginger and Black Pepper – Each gummy contains turmeric, ginger, and black pepper to support nutrient absorption, making it easy to take consistently.
• No Artificial Colors, Soy, Dairy, or Gluten – Clean turmeric and ginger gummies made without dairy, soy, gluten, or artificial additives. Safe and simple for everyday use.

Turmeric’s active compound curcumin is a potent anti-inflammatory that supports healthy endothelial function and may help reduce the vascular inflammation driving secondary Raynaud’s.

Lunakai’s Turmeric Gummies combine high-absorption turmeric with ginger and BioPerine for enhanced bioavailability. For Raynaud’s patients — especially those with secondary Raynaud’s linked to autoimmune conditions — chronic vascular inflammation contributes to impaired blood vessel function. Curcumin has demonstrated the ability to improve endothelial function, reduce oxidative stress in blood vessels, and modulate inflammatory pathways. Ginger provides additional warming and circulation-boosting properties that the Raynaud’s Association recommends for symptom management.

• Pros:
• Addresses vascular inflammation underlying Raynaud’s
• BioPerine enhances curcumin absorption by 2,000%
• Ginger provides additional warming and circulation benefits

• Cons:
• Not specifically studied for Raynaud’s
• Gummy form contains added sugars

Best for: Raynaud’s patients with secondary Raynaud’s linked to autoimmune conditions who need anti-inflammatory and circulation support

How to Choose the Best Supplement for Raynaud’s Syndrome

The most effective supplement approach for Raynaud’s targets three mechanisms: nitric oxide production for vasodilation (L-arginine, L-citrulline), smooth muscle relaxation (magnesium), and inflammation reduction (omega-3s, evening primrose oil, turmeric). Since Raynaud’s involves exaggerated vasoconstriction, supplements that mimic or support the action of calcium channel blockers — the most commonly prescribed medications — offer the most logical starting point. Magnesium is the clearest example, as it naturally blocks calcium-mediated vessel constriction.

Distinguish between primary and secondary Raynaud’s when selecting supplements. Primary Raynaud’s (no underlying condition) responds well to L-arginine, fish oil, and evening primrose oil based on available clinical evidence. Secondary Raynaud’s (associated with autoimmune diseases like scleroderma or lupus) may benefit more from anti-inflammatory supplements like omega-3s, turmeric, and antioxidants that address the underlying vascular damage.

Dosage matters significantly for Raynaud’s supplements. Clinical studies used L-arginine at 1,500-6,000mg daily, magnesium at 500mg daily, and fish oil providing approximately 3-4 grams of EPA/DHA daily. These are higher than typical supplement label suggestions, so work with a healthcare provider to determine appropriate doses. Warming herbs like ginger, cayenne, and cinnamon can complement supplements through dietary inclusion.

Safety considerations include avoiding L-arginine if taking PDE-5 inhibitors or nitrate medications, and consulting a provider before combining fish oil or evening primrose oil with blood-thinning medications. Start one supplement at a time, allowing 4-6 weeks to assess effects before adding another.

Frequently Asked Questions

What is Raynaud’s syndrome and can supplements help?

Raynaud’s syndrome (Raynaud’s phenomenon) is a vascular disorder where blood vessels in the extremities overreact to cold or stress, causing episodic color changes (white, blue, red), numbness, tingling, and pain — primarily in fingers and toes. Supplements can help by supporting nitric oxide production for vasodilation, relaxing smooth muscles in blood vessel walls, reducing blood viscosity for better microcirculation, and addressing vascular inflammation. While not a cure, several supplements have clinical evidence for reducing attack frequency and severity.

What is the most effective supplement for Raynaud’s?

L-arginine has the most direct clinical evidence, with case reports showing it can reverse digital necrosis in severe Raynaud’s by boosting nitric oxide production. Fish oil and evening primrose oil both have positive randomized trial data for primary Raynaud’s. Magnesium addresses the same mechanism (calcium channel blocking) as the most commonly prescribed Raynaud’s medication. A combination approach targeting multiple mechanisms typically produces the best results.

How long do Raynaud’s supplements take to work?

Most circulation-supporting supplements require 4-8 weeks of consistent use before noticeable improvement. Fish oil studies showed benefits at the 12-week mark, while evening primrose oil showed results after 8 weeks. L-arginine may work more quickly for some patients since nitric oxide production can increase within days, though clinical benefits accumulate over weeks. Magnesium’s smooth muscle relaxation effects can begin within 2-4 weeks of reaching adequate levels.

Can I take Raynaud’s supplements with calcium channel blockers?

Magnesium works through the same mechanism as calcium channel blockers and should be discussed with a prescriber to avoid excessive vasodilation or blood pressure drops. L-arginine should be used cautiously with PDE-5 inhibitors and nitrate medications. Fish oil, evening primrose oil, and turmeric are generally safe alongside calcium channel blockers but may have additive blood-thinning effects. Always inform your healthcare provider about all supplements you take.

Are there lifestyle changes that enhance supplement effectiveness for Raynaud’s?

Absolutely. Layer clothing effectively, focusing on core warmth (not just hands). Avoid smoking, which dramatically worsens vasoconstriction. Reduce caffeine and alcohol intake. Incorporate warming foods like ginger, cayenne pepper, cinnamon, and garlic into your diet. Manage stress through relaxation techniques, as emotional stress triggers attacks. Regular exercise improves overall circulation. Chemical hand warmers and heated gloves provide immediate relief during attacks.

Is there a difference between supplements for primary vs. secondary Raynaud’s?

Yes. Primary Raynaud’s (no underlying disease) responds better to vasodilatory supplements like L-arginine, fish oil, and evening primrose oil. Secondary Raynaud’s (associated with autoimmune conditions like scleroderma or lupus) benefits from anti-inflammatory and antioxidant supplements like omega-3s, turmeric, and Vitamin E that address underlying vascular damage and autoimmune inflammation. Both types benefit from magnesium supplementation. Secondary Raynaud’s is generally more severe and should be managed under medical supervision.

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